Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.62 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.62 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.62 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GABRP | O00591 | 2/20 | 0.46 |
| ▸ | GABRD | O14764 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.46 |
| ▸ | GABRE | P78334 | 2/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL6131152 | 0.96 | GPR84 (0.54) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL5665994 | 0.96 | GPR84 (0.54) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL31157624 | 0.96 | GPR84 (0.54) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Sebacic Acid SCHEMBL25336327 | 0.93 | GPR84 (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Azelaic Acid SCHEMBL28859389 | 0.93 | GPR84 (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Pimelic Acid SCHEMBL30288567 | 0.93 | GPR84 (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Glutarate SCHEMBL30288574 | 0.91 | SLC22A6 (0.52) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| SCHEMBL8984604 | 0.89 | GPR84 (0.67) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| SCHEMBL8984358 | 0.89 | GPR84 (0.67) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| SCHEMBL8044968 | 0.89 | GPR84 (0.67) | GPR84FFAR1FFAR4CAMK2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110105525-B | NDI-based polyurethane microporous elastomer resistant to damp-heat aging and preparation method thereof | 株洲时代新材料科技股份有限公司 | 2021-11-16 | — | — | CN | disclosed |