Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 12/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.47 |
| ▸ | LOXL3 | P58215 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | LOX | P28300 | 7/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29971595 | 1.00 | LOXL2 (0.62) | LOXL2KCNH2AOC3LOXL3MAOB | |
| SCHEMBL19259776 | 0.87 | LOXL2 (0.71) | LOXL2KCNH2AOC3LOXL3MAOB | |
| SCHEMBL29970998 | 0.87 | LOXL2 (0.64) | LOXL2KCNH2AOC3LOXL3MAOA | |
| SCHEMBL28641800 | 0.87 | LOXL2 (0.64) | LOXL2KCNH2AOC3LOXL3MAOA | |
| SCHEMBL19274424 | 0.84 | LOX (0.50) | LOXL2MAOALOXCA12CA1 | |
| SCHEMBL28644342 | 0.80 | LOXL2 (0.63) | LOXL2KCNH2AOC3LOXL3MAOA | |
| SCHEMBL21016658 | 0.80 | LOX (0.44) | LOXL2MAOALOXCA12CA1 | |
| SCHEMBL30699853 | 0.79 | LOXL2 (0.48) | LOXL2KCNH2AOC3LOXL3MAOB | |
| SCHEMBL19274856 | 0.78 | HDAC1 (0.41) | LOXL2HDAC1CTSBCTSSCTSK | |
| SCHEMBL19274294 | 0.77 | LOX (0.53) | LOXL2MAOALOXCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311839-B | Methylamine derivatives as lysyl oxidase inhibitors for the treatment of cancer | 癌症研究协会皇家癌症医院 | 2021-11-02 | — | — | CN | disclosed |