Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13224505 | 0.93 | MAPT (0.89) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL12605599 | 0.89 | MAPT (0.76) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL12109319 | 0.88 | MAPT (0.81) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL31914 | 0.88 | MAPT (1.00) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL28649151 | 0.85 | MAPT (0.81) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL22452889 | 0.85 | MAPT (0.76) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL13832955 | 0.85 | MAPT (0.76) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL22853361 | 0.85 | MAPT (0.76) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL5993324 | 0.85 | MAPT (0.76) | MAPTALOX15SIRT2KDM4EPOLB | |
| SCHEMBL17617073 | 0.85 | MAPT (0.76) | MAPTALOX15SIRT2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117043154-A | GPCR receptor agonists, pharmaceutical compositions comprising same, and methods of use thereof | 卡莫特医疗有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-113768936-B | Application of evodiamine derivative in preparation of medicine for treating superficial fungal infection | 南华大学 | 2023-04-14 | — | — | CN | disclosed |
| CN-113768936-A | Application of evodiamine derivative in preparation of medicine for treating superficial fungal infection | 南华大学 | 2021-12-10 | — | — | CN | disclosed |