Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | VNN1 | O95497 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28655635 | 0.90 | KDM4E (0.46) | PTPN1HDAC8HDAC1HDAC6MEN1 | |
| SCHEMBL28662381 | 0.88 | L3MBTL1 (0.54) | PTPN1MEN1KMT2AL3MBTL1GAA | |
| SCHEMBL28668176 | 0.88 | KMT2A (0.49) | PTPN1HDAC8MEN1KMT2AHTT | |
| SCHEMBL28928914 | 0.84 | KMT2A (0.61) | MEN1KMT2AL3MBTL1GAAMAPT | |
| SCHEMBL30358562 | 0.82 | CA12 (0.57) | HDAC8HDAC1HDAC6MEN1KMT2A | |
| SCHEMBL9956587 | 0.82 | CA12 (0.57) | HDAC8HDAC1HDAC6MEN1KMT2A | |
| SCHEMBL31643877 | 0.80 | CYP3A4 (0.51) | PTPN1HDAC8HDAC1HDAC6MEN1 | |
| SCHEMBL22836927 | 0.78 | AKR1C3 (0.63) | L3MBTL1ALDH1A1KDM4EASPHRIOX2 | |
| SCHEMBL10787691 | 0.77 | RAB9A (0.55) | MEN1KMT2AGAAMAPTSMN1; SMN2 | |
| SCHEMBL30691740 | 0.77 | HDAC8 (0.60) | HDAC8HDAC1HDAC6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116270577-A | Application of polysubstituted benzene compounds in preparation of medicines for treating cognitive impairment diseases, structure and preparation method | 中国医学科学院医药生物技术研究所 | 2023-06-23 | — | — | CN | disclosed |
| CN-116270576-A | Application of polysubstituted benzene compounds in preparation of medicines for treating cognitive impairment diseases, structure and preparation method | 中国医学科学院医药生物技术研究所 | 2023-06-23 | — | — | CN | disclosed |
| CN-113521048-B | Application of polysubstituted benzene compound in preparation of medicine for treating cognitive disorder diseases, structure and preparation method | 中国医学科学院医药生物技术研究所 | 2023-04-14 | — | — | CN | disclosed |
| CN-113521048-A | Application of polysubstituted benzene compound in preparation of medicine for treating cognitive disorder diseases, structure and preparation method | 中国医学科学院医药生物技术研究所 | 2021-10-22 | — | — | CN | disclosed |