Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 3/20 | 0.45 |
| ▸ | F3 | P13726 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ECE1 | P42892 | 1/20 | 0.45 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.45 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 5/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | BID | P55957 | 3/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28660083 | 1.00 | PTGES (0.51) | PTGESSLC37A4F7F3MMP2 | |
| SCHEMBL28672295 | 0.89 | FLT3 (0.52) | PTGESFLT3CNR1CNR2 | |
| SCHEMBL28672294 | 0.89 | FLT3 (0.52) | PTGESFLT3CNR1CNR2 | |
| SCHEMBL23630585 | 0.85 | PTPN1 (0.50) | PTGESF7F3MMP2KDM4E | |
| SCHEMBL28658973 | 0.79 | CNR1 (0.47) | SLC37A4KDM4EMAPTALOX15CNR1 | |
| SCHEMBL28658975 | 0.79 | CNR1 (0.47) | SLC37A4KDM4EMAPTALOX15CNR1 | |
| SCHEMBL10756858 | 0.78 | FLT3 (0.45) | PTGESKDM4EMAPTHSD17B10FLT3 | |
| SCHEMBL4148092 | 0.76 | F7 (0.66) | SLC37A4F7F3MMP2KDM4E | |
| SCHEMBL4148088 | 0.76 | F7 (0.66) | SLC37A4F7F3MMP2KDM4E | |
| SCHEMBL21815453 | 0.76 | PTPN1 (0.61) | PTGESALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116270577-A | Application of polysubstituted benzene compounds in preparation of medicines for treating cognitive impairment diseases, structure and preparation method | 中国医学科学院医药生物技术研究所 | 2023-06-23 | — | — | CN | disclosed |
| CN-116270576-A | Application of polysubstituted benzene compounds in preparation of medicines for treating cognitive impairment diseases, structure and preparation method | 中国医学科学院医药生物技术研究所 | 2023-06-23 | — | — | CN | disclosed |
| CN-113521048-B | Application of polysubstituted benzene compound in preparation of medicine for treating cognitive disorder diseases, structure and preparation method | 中国医学科学院医药生物技术研究所 | 2023-04-14 | — | — | CN | disclosed |
| CN-113521048-A | Application of polysubstituted benzene compound in preparation of medicine for treating cognitive disorder diseases, structure and preparation method | 中国医学科学院医药生物技术研究所 | 2021-10-22 | — | — | CN | disclosed |