SCHEMBL28660906

SCHEMBL28660906

FB(F)F.[K]Cc1ccc(Br)cc1

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.41
HTR2A P28223 1/20 0.41
CYP2A6 P11509 1/20 0.40
IDO1 P14902 4/20 0.39
PYCR1 P32322 2/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
TSHR P16473 1/20 0.33
LMNA P02545 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
AGER Q15109 1/20 0.32
APP P05067 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28660908 0.85 TAAR1 (0.41) TAAR1HTR2ACYP2A6IDO1PYCR1
SCHEMBL28659468 0.77 IDO1 (0.46) TAAR1IDO1LMNA
SCHEMBL28675261 0.75 IDO1 (0.44) TAAR1HTR2ACYP2A6IDO1LMNA
SCHEMBL28656019 0.75 IDO1 (0.44) TAAR1CYP2A6IDO1CA1CA2
SCHEMBL25181504 0.74 CALM1 (0.43) TAAR1HTR2ACYP2A6IDO1CA1
SCHEMBL28671397 0.70 CYP2A6 (0.47) TAAR1CYP2A6CA1CA2TSHR
SCHEMBL28660909 0.70 IDO1 (0.50) TAAR1IDO1CA1CA2TSHR
SCHEMBL29446040 0.68 HTT (0.42)
SCHEMBL28713315 0.68 HTT (0.42)
SCHEMBL2517808 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110294776-B Method for preparing aryl phosphine oxide derivative 苏州大学 2021-12-10 CN disclosed