Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CCR9 | P51686 | 1/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19268458 | 1.00 | AAK1 (0.44) | AAK1USP30CCR9PCSK9SERPINE1 | |
| SCHEMBL5356345 | 0.91 | AAK1 (0.44) | AAK1USP30CCR9PCSK9SERPINE1 | |
| SCHEMBL5356339 | 0.91 | AAK1 (0.44) | AAK1USP30CCR9PCSK9SERPINE1 | |
| SCHEMBL19252910 | 0.91 | AAK1 (0.45) | AAK1USP30CCR9PCSK9CTSS | |
| SCHEMBL19252909 | 0.91 | AAK1 (0.45) | AAK1USP30CCR9PCSK9CTSS | |
| SCHEMBL19268460 | 0.82 | PCSK9 (0.38) | AAK1PCSK9SERPINE1SUV39H2 | |
| SCHEMBL1980013 | 0.80 | SERPINE1 (0.40) | SERPINE1MAPT | |
| SCHEMBL5351582 | 0.77 | SYK (0.36) | AAK1PCSK9SERPINE1MAPT | |
| SCHEMBL5351591 | 0.77 | SYK (0.36) | AAK1PCSK9SERPINE1MAPT | |
| SCHEMBL7095593 | 0.77 | NOD2 (0.45) | PCSK9SERPINE1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113620950-A | Carboxamide derivatives useful as RSK inhibitors | 凤凰分子设计公司 | 2021-11-09 | — | — | CN | disclosed |
| CN-109071542-B | Carboxamide derivatives useful as RSK inhibitors | 凤凰分子设计公司 | 2021-07-20 | — | — | CN | disclosed |