Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28039442 | 0.96 | HIF1A (0.58) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL2410568 | 0.94 | HIF1A (0.56) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL10842501 | 0.92 | HIF1A (0.50) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL10375203 | 0.92 | HIF1A (0.54) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL2449969 | 0.89 | HIF1A (0.74) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL164818 | 0.86 | HIF1A (0.71) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL11440559 | 0.84 | HIF1A (0.56) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL7970758 | 0.84 | HIF1A (0.74) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL2446042 | 0.84 | HIF1A (0.74) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL11753850 | 0.83 | HIF1A (0.54) | HIF1AALDH1A1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9464048-B2 | 5-oxo-ETE receptor antagonist compounds | FLORIDA INSTITUTE OF TECHNOLOGY (US) | 2016-10-11 | — | — | US | disclosed |
| EP-2495242-B1 | NOVEL VASCULAR LEAK INHIBITOR | UNIV YONSEI IACF (KR) | 2016-05-04 | — | — | EP | disclosed |
| CN-102656153-B | Novel vascular leak inhibitor | UNIV YONSEI IACF (KR) | 2015-02-18 | — | — | CN | disclosed |
| US-8889840-B2 | Vascular leakage inhibitor | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2014-11-18 | — | — | US | disclosed |
| US-20140323535-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2014-10-30 | — | — | US | disclosed |
| EP-2427430-B1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | UNIV MCGILL (CA) | 2014-09-10 | — | — | EP | disclosed |
| US-8809382-B2 | 5-oxo-ETE receptor antagonist compounds | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2014-08-19 | — | — | US | disclosed |
| US-20120245110-A1 | VASCULAR LEAKAGE INHIBITOR | CURACLE CO., LTD. (KR) | 2012-09-27 | — | — | US | disclosed |
| EP-2495242-A2 | NOVEL VASCULAR LEAK INHIBITOR | Industry-Academic Cooperation Foundation, Yonsei University (KR) | 2012-09-05 | — | — | EP | disclosed |
| CN-102656153-A | Novel vascular leak inhibitor | HANDOK PHARMACEUTICALS CO LTD | 2012-09-05 | — | — | CN | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0295294-A4 | PEPTIDYLAMINODIOLS. | ABBOTT LAB (US) | 1990-04-10 | — | — | EP | disclosed |
| US-4880892-A | PHOSPHONIUM OR PHOSPHORANE CATALYST, PROTECTIVE COATINGS | CIBA-GEIGY CORPORATION (US) | 1989-11-14 | — | — | US | disclosed |
| US-4845079-A | HYPOTENSIVE, RENIN INHIBITION | ABBOTT LABORATORIES | 1989-07-04 | — | — | US | disclosed |
| EP-0295294-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-12-21 | — | — | EP | disclosed |
| WO-1988005050-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-07-14 | — | — | WO | disclosed |
| EP-0229667-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1987-07-22 | — | — | EP | disclosed |
| EP-0189203-A2 | Peptidylaminodiols | ABBOTT LABORATORIES (US) | 1986-07-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323535-A1 | 5-OXO-ETE RECEPTOR ANTAGONIST COMPOUNDS | OXER1, PTGIR, EDNRA | HIF1A 867/4885ALDH1A1 1506/4885CYP1A2 517/4885 |
| US-20120245110-A1 | VASCULAR LEAKAGE INHIBITOR | LIPG, VCAM1, ARHGDIB | HIF1A 2987/4885ALDH1A1 4675/4885CYP1A2 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.