Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 6/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19029939 | 0.82 | LMNA (0.47) | KDM4EALDH1A1PDE2AIRAK4HSD11B1 | |
| SCHEMBL12505413 | 0.80 | IRAK4 (0.43) | KDM4EALDH1A1TDP1PDE2AIRAK4 | |
| SCHEMBL310362 | 0.79 | HSD11B1 (0.49) | KDM4EALDH1A1TDP1PDE2AIRAK4 | |
| SCHEMBL310187 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1TDP1PDE2AIRAK4 | |
| SCHEMBL310126 | 0.79 | PDE2A (0.59) | KDM4EALDH1A1TDP1PDE2AHSD11B1 | |
| SCHEMBL309283 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1TDP1PDE2AIRAK4 | |
| SCHEMBL308924 | 0.77 | KDM4E (0.42) | KDM4EALDH1A1TDP1PDE2AIRAK4 | |
| SCHEMBL12505460 | 0.76 | IRAK4 (0.43) | KDM4EALDH1A1TDP1PDE2AIRAK4 | |
| SCHEMBL14033080 | 0.76 | KDM4E (0.40) | KDM4EALDH1A1TDP1PDE2APOLB | |
| SCHEMBL357836 | 0.76 | LMNA (0.45) | KDM4EALDH1A1TDP1PDE2AIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |