Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.48 |
| ▸ | LGMN | Q99538 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19030334 | 0.90 | IRAK4 (0.45) | IRAK4LGMNKDM4EALDH1A1LMNA | |
| SCHEMBL19030064 | 0.86 | IRAK4 (0.47) | IRAK4LGMNKDM4EALDH1A1LMNA | |
| SCHEMBL19046031 | 0.82 | IRAK4 (0.50) | IRAK4LGMNKDM4EALDH1A1LMNA | |
| SCHEMBL19029902 | 0.81 | IRAK4 (0.42) | IRAK4SMN1; SMN2 | |
| SCHEMBL19029997 | 0.81 | IRAK4 (0.47) | IRAK4LGMNKDM4EALDH1A1LMNA | |
| SCHEMBL19030771 | 0.81 | IRAK4 (0.49) | IRAK4LGMNKDM4EALDH1A1LMNA | |
| SCHEMBL19029917 | 0.80 | IRAK4 (0.52) | IRAK4LGMNKDM4EALDH1A1 | |
| SCHEMBL28655900 | 0.80 | IRAK4 (0.47) | IRAK4KDM4EALDH1A1LMNAGAA | |
| SCHEMBL19030684 | 0.79 | LGMN (0.45) | IRAK4LGMN | |
| SCHEMBL23110742 | 0.78 | IRAK4 (0.40) | IRAK4KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |