SCHEMBL28670569

SCHEMBL28670569

COC(=O)c1ccc(C2(O)CCC2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
TDP1 Q9NUW8 1/20 0.50
CA12 O43570 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
CA14 Q9ULX7 1/20 0.50
TSHR P16473 1/20 0.47
MAPT P10636 4/20 0.46
ALDH1A1 P00352 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
HSP90AA1 P07900 1/20 0.46
LOXL2 Q9Y4K0 1/20 0.44
CYP2D6 P10635 1/20 0.44
HPGD P15428 1/20 0.44
GRIN2B Q13224 2/20 0.44
PKM P14618 1/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
RAB9A P51151 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17869073 0.93 CA1 (0.53) CA1CA2TDP1CA12CA7
SCHEMBL25330988 0.85 PKM (0.47) CA1CA2TDP1CA12CA7
SCHEMBL612696 0.85 MAPT (0.46) CA1CA2TDP1CA12CA7
SCHEMBL25331702 0.85 ALDH1A1 (0.51) CA1CA2TDP1CA12CA7
SCHEMBL25992742 0.82 MAPT (0.44) CA1CA2TDP1CA12CA7
SCHEMBL613744 0.81 ALDH1A1 (0.44) CA1CA2TDP1CA12CA7
SCHEMBL24861978 0.81 AKT1 (0.53) CA1CA2TDP1CA12CA7
SCHEMBL28166412 0.81 CA1 (0.48) CA1CA2TDP1CA12CA7
SCHEMBL20703721 0.79 AKR1C1 (0.53) CA1CA2TDP1CA12CA7
SCHEMBL2245739 0.78 CA1 (0.65) CA1CA2TDP1CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110218227-B Method for preparing aryl ketone derivative 苏州大学 2021-12-10 CN disclosed