SCHEMBL28670969

SCHEMBL28670969

CCOC(=O)CCCCNc1cccc2cccc(Cl)c12

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 2/20 0.46
ALDH1A1 P00352 2/20 0.45
HTT P42858 1/20 0.44
MAPT P10636 3/20 0.44
KDM4E B2RXH2 1/20 0.43
NLRP3 Q96P20 1/20 0.42
NAMPT P43490 1/20 0.42
PDE5A O76074 1/20 0.42
ELANE P08246 1/20 0.42
CYP4F2 P78329 1/20 0.40
CYP4A11 Q02928 1/20 0.40
ALOX15 P16050 1/20 0.40
LTA4H P09960 1/20 0.40
LMNA P02545 1/20 0.40
POLB P06746 1/20 0.40
GPR35 Q9HC97 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12406999 0.82 ALDH1A1 (0.58) TOP2AALDH1A1HTTMAPTKDM4E
SCHEMBL28667127 0.81 TOP2A (0.58) TOP2AALDH1A1MAPTKDM4EPDE5A
SCHEMBL30887678 0.80 MAPT (0.54) ALDH1A1HTTMAPTKDM4ENLRP3
SCHEMBL28669591 0.80 MAPT (0.54) ALDH1A1HTTMAPTKDM4ENLRP3
SCHEMBL22945078 0.80 TOP2A (0.57) TOP2AALDH1A1MAPTKDM4ENAMPT
SCHEMBL1672450 0.80 TOP2A (0.48) TOP2AALDH1A1MAPTKDM4ENAMPT
SCHEMBL9829339 0.77 MAPT (0.51) TOP2AALDH1A1HTTMAPTNLRP3
SCHEMBL9831014 0.76 TOP2A (0.53) TOP2AALDH1A1HTTMAPTNLRP3
SCHEMBL24277389 0.74 ALDH1A1 (0.46) TOP2AALDH1A1MAPTKDM4ENAMPT
SCHEMBL25142537 0.74 ALDH1A1 (0.49) TOP2AALDH1A1MAPTKDM4ENAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113135924-B Pyrimidine derivatives and their use in medicine 广东东阳光药业股份有限公司 2024-04-26 CN disclosed
CN-113135924-A Pyrimidine derivatives and their use in medicine 广东东阳光药业有限公司 2021-07-20 CN disclosed