Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30887678 | 1.00 | MAPT (0.54) | MAPTHTTALDH1A1NLRP3LMNA | |
| SCHEMBL28670969 | 0.80 | TOP2A (0.46) | MAPTHTTALDH1A1NLRP3LMNA | |
| SCHEMBL15551545 | 0.75 | HTT (0.58) | MAPTHTTALDH1A1NLRP3LMNA | |
| SCHEMBL31376456 | 0.75 | HTT (0.58) | MAPTHTTALDH1A1NLRP3LMNA | |
| SCHEMBL28668318 | 0.74 | ALDH1A1 (0.48) | MAPTALDH1A1NLRP3LMNASMN1; SMN2 | |
| SCHEMBL28661726 | 0.73 | NLRP3 (0.39) | MAPTHTTALDH1A1NLRP3LMNA | |
| SCHEMBL11305630 | 0.72 | NLRP3 (0.52) | MAPTHTTALDH1A1NLRP3LMNA | |
| SCHEMBL10487935 | 0.71 | HTT (0.54) | MAPTHTTALDH1A1NLRP3LMNA | |
| SCHEMBL6826906 | 0.70 | HTT (0.53) | MAPTHTTALDH1A1NLRP3LMNA | |
| SCHEMBL697406 | 0.70 | HPGD (0.64) | MAPTALDH1A1LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135924-B | Pyrimidine derivatives and their use in medicine | 广东东阳光药业股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-113135924-A | Pyrimidine derivatives and their use in medicine | 广东东阳光药业有限公司 | 2021-07-20 | — | — | CN | disclosed |