SCHEMBL28673267

SCHEMBL28673267

FC(F)(F)c1oc(C=Cc2ccccc2)nc1-c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.45
SMN1; SMN2 Q16637 6/20 0.45
NPC1 O15118 5/20 0.45
TDP1 Q9NUW8 2/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
RXRA P19793 3/20 0.44
RXRB P28702 3/20 0.44
RXRG P48443 2/20 0.44
ELANE P08246 1/20 0.43
NR4A1 P22736 1/20 0.41
NR4A2 P43354 1/20 0.41
NR4A3 Q92570 1/20 0.41
CASP3 P42574 4/20 0.40
SENP8 Q96LD8 4/20 0.40
SENP7 Q9BQF6 4/20 0.40
SENP6 Q9GZR1 3/20 0.40
ALDH1A1 P00352 4/20 0.39
KDM4E B2RXH2 4/20 0.39
HPGD P15428 4/20 0.39
MAPT P10636 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28673263 1.00 RAB9A (0.45) RAB9ASMN1; SMN2NPC1TDP1L3MBTL1
SCHEMBL18409750 0.74 RXRA (0.58) RAB9ARXRARXRBRXRGNR4A1
SCHEMBL26604323 0.74 SMO (0.57) RAB9ASMN1; SMN2NPC1ALDH1A1KDM4E
SCHEMBL3898834 0.72 NPC1 (0.51) NPC1TDP1L3MBTL1ALDH1A1KDM4E
SCHEMBL28664350 0.70 SMO (0.51) ALDH1A1KDM4EHPGDPTGS1SMO
SCHEMBL3897525 0.69 ELANE (0.41) RXRARXRBRXRGELANENR4A1
SCHEMBL5210630 0.69 KDM4E (0.44) RAB9ASMN1; SMN2NPC1TDP1L3MBTL1
SCHEMBL5210635 0.69 KDM4E (0.44) RAB9ASMN1; SMN2NPC1TDP1L3MBTL1
SCHEMBL5211886 0.68 RXRA (0.49) RAB9ASMN1; SMN2NPC1TDP1L3MBTL1
SCHEMBL28664345 0.68 SMO (0.55) NPC1ALDH1A1KDM4EKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113717121-A Preparation method of 5-fluoroalkyl substituted oxazole compound 南开大学 2021-11-30 CN disclosed