Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19689701 | 0.85 | ALDH1A1 (0.51) | GPR119ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL19689700 | 0.81 | GPR119 (0.47) | GPR119ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL380505 | 0.81 | DHODH (0.49) | GPR119ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL30527088 | 0.81 | DHODH (0.49) | GPR119ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL21724876 | 0.80 | GPR119 (0.46) | GPR119ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL30681278 | 0.79 | GPR119 (0.45) | GPR119ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL846218 | 0.79 | HDAC1 (0.53) | GPR119ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL19689717 | 0.78 | GPR119 (0.47) | GPR119DHODHMPOABHD6NR1H2 | |
| SCHEMBL21042103 | 0.77 | GPR119 (0.45) | GPR119ALDH1A1KDM4EHPGDRECQL | |
| SCHEMBL19689708 | 0.77 | GPR119 (0.47) | GPR119ALDH1A1MAPTDHODHSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641881-B | 1-tetrahydropyranyl carbonyl-2, 3-dihydro-1H-indole compounds for use in the treatment of cancer | 伊莱利利公司 | 2022-01-07 | — | — | CN | disclosed |