SCHEMBL28675220

SCHEMBL28675220

O=c1nc(-c2ccccc2Cl)nc(-c2ccccc2)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.53
CYP3A4 P08684 2/20 0.53
CYP2D6 P10635 2/20 0.53
CYP2C9 P11712 2/20 0.53
CYP2C19 P33261 2/20 0.53
NPC1 O15118 2/20 0.53
HPGD P15428 2/20 0.53
RAB9A P51151 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
TP53 P04637 1/20 0.53
ALPL P05186 1/20 0.53
NR1H2 P55055 1/20 0.53
NR1H3 Q13133 1/20 0.53
MAPK13 O15264 1/20 0.49
RAF1 P04049 1/20 0.49
MAPK12 P53778 1/20 0.49
MAPK11 Q15759 1/20 0.49
MAPK14 Q16539 1/20 0.49
GUSB P08236 1/20 0.47
CYP2A6 P11509 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28682263 0.88 NPC1 (0.60) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL28677334 0.81 MAPT (0.53) CYP1A2NPC1HPGDRAB9ASMN1; SMN2
SCHEMBL28677343 0.81 NR1H2 (0.53) HPGDRAB9ASMN1; SMN2TP53NR1H2
SCHEMBL28682476 0.79 NR1H2 (0.59) CYP3A4HPGDTP53NR1H2NR1H3
SCHEMBL28681348 0.77 PIN1 (0.51) CYP3A4HPGDTP53MAPK13RAF1
SCHEMBL30672042 0.77 PIN1 (0.51) CYP3A4HPGDTP53MAPK13RAF1
SCHEMBL646494 0.76 NR1H2 (0.76) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL28681344 0.75 SMN1; SMN2 (0.53) NPC1HPGDRAB9ASMN1; SMN2TP53
SCHEMBL28685099 0.74 GSK3B (0.56) HPGDMAPK13RAF1MAPK12MAPK11
SCHEMBL28694192 0.74 NR1H2 (0.61) CYP1A2CYP3A4CYP2C9CYP2C19NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113173889-B Method for synthesizing 1,3, 5-triazine derivative 新乡市润宇新材料科技有限公司 2023-11-10 CN disclosed
CN-113173889-A Method for synthesizing 1,3, 5-triazine derivative 新乡市润宇新材料科技有限公司 2021-07-27 CN disclosed