Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27901846 | 0.81 | KDM4E (0.58) | SMN1; SMN2HPGDKMT2AMEN1GLA | |
| SCHEMBL14951425 | 0.80 | MEN1 (0.56) | SMN1; SMN2HPGDKMT2AMEN1POLB | |
| SCHEMBL18192027 | 0.77 | AGTR1 (0.55) | SMN1; SMN2HPGDKMT2AMEN1KDM4E | |
| SCHEMBL30609019 | 0.77 | AGTR1 (0.55) | SMN1; SMN2HPGDKMT2AMEN1KDM4E | |
| SCHEMBL28928751 | 0.76 | MEN1 (0.35) | SMN1; SMN2HPGDKMT2AMEN1GLA | |
| SCHEMBL22065910 | 0.76 | KDM4E (0.52) | SMN1; SMN2HPGDKMT2AMEN1GLA | |
| SCHEMBL603975 | 0.75 | KDM4E (0.59) | SMN1; SMN2HPGDKMT2AMEN1GLA | |
| SCHEMBL22064956 | 0.75 | KDM4E (0.67) | SMN1; SMN2HPGDKMT2AMEN1GLA | |
| SCHEMBL28108912 | 0.75 | AGTR1 (0.49) | SMN1; SMN2HPGDKMT2AMEN1KDM4E | |
| SCHEMBL16125570 | 0.74 | RAD51 (0.37) | SMN1; SMN2HPGDKMT2AMEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113024534-B | 2-pyridylthiazole derivatives and use thereof | 武汉光谷亚太医药研究院有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-113024534-A | 2-pyridylthiazole derivatives and use thereof | 武汉光谷亚太医药研究院有限公司 | 2021-06-25 | — | — | CN | disclosed |