Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | CDC25C | P30307 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | APC | P25054 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28683437 | 0.90 | MAPT (0.55) | MAPTGAAS1PR1NPC1LMNA | |
| SCHEMBL28667773 | 0.88 | MAPT (0.62) | MAPTGAANPC1LMNAHTT | |
| SCHEMBL28681669 | 0.85 | MAPT (0.56) | MAPTGAANPC1LMNAHTT | |
| SCHEMBL28665720 | 0.85 | MAPT (0.54) | MAPTGAALMNATHRBTSHR | |
| SCHEMBL28688233 | 0.84 | S1PR1 (0.56) | MAPTGAAS1PR1NPC1LMNA | |
| SCHEMBL28930626 | 0.83 | MAPT (0.68) | MAPTGAALMNATHRBTP53 | |
| SCHEMBL28688168 | 0.83 | MAPT (0.53) | MAPTGAAS1PR1NPC1THRB | |
| SCHEMBL28665714 | 0.80 | MAPT (0.64) | MAPTGAANPC1LMNAHTT | |
| SCHEMBL28661668 | 0.79 | MAPT (0.51) | MAPTGAALMNATHRBTP53 | |
| SCHEMBL28665641 | 0.78 | MAPT (0.58) | MAPTGAANPC1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108658889-B | 1,2, 4-oxadiazole-aryl piperazine compound containing naphthalene ring and preparation method and application thereof | 贵州医科大学 | 2021-12-17 | — | — | CN | disclosed |