Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28688126 | 0.89 | KDM4E (0.59) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL28696921 | 0.85 | KDM4E (0.54) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL28691780 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL28681143 | 0.82 | KDM4E (0.51) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL28682193 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL20155102 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL28681705 | 0.79 | AR (0.50) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL3356525 | 0.79 | KDM4E (0.50) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL28677203 | 0.77 | AR (0.53) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL2033529 | 0.77 | KDM4E (0.56) | KDM4EALDH1A1USP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109651208-B | N-aryl sulfonamide compound, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2022-01-04 | — | — | CN | disclosed |