Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14804393 | 0.71 | NPC1 (0.56) | GPR84NOTUMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8360193 | 0.68 | PKM (0.71) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4485602 | 0.68 | GPR84 (0.35) | GPR84NOTUMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL225238 | 0.67 | GPR84 (0.43) | GPR84NOTUMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL739207 | 0.66 | NPC1 (0.67) | GPR84NOTUMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2838194 | 0.66 | GPR84 (0.36) | GPR84NOTUMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL225236 | 0.66 | NPC1 (0.42) | GPR84NOTUMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13612274 | 0.65 | TP53 (0.65) | GPR84RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2870077 | 0.64 | GPR84 (0.35) | GPR84NOTUMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8126280 | 0.64 | NPC1 (0.48) | GPR84NOTUMRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039913-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |