Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28680547 | 1.00 | CHRNB2 (0.46) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL20412703 | 0.89 | HRH1 (0.47) | HTR1ASLC6A2PIM1ROCK1HTR2C | |
| Hydrochloric Acid SCHEMBL28677440 | 0.88 | HRH1 (0.46) | HTR1ASLC6A2ROCK1HTR2C | |
| SCHEMBL18291292 | 0.87 | CHRNB2 (0.44) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL18291432 | 0.83 | CHRNB2 (0.44) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL20249279 | 0.83 | CHRNB2 (0.41) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL28670808 | 0.82 | CHRNB2 (0.50) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL28670810 | 0.82 | CHRNB2 (0.50) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL23791606 | 0.80 | CHRNB2 (0.41) | CHRNB2CHRNA4PRKCZHTR1ASLC6A2 | |
| SCHEMBL28664210 | 0.80 | CHRNB2 (0.55) | CHRNB2CHRNA4PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-B | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2021-12-14 | — | — | CN | disclosed |