Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.61 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31256928 | 1.00 | CHRM4 (0.61) | CHRM4DUSP3ADORA2BADORA2AADORA1 | |
| SCHEMBL3042846 | 0.84 | CHRM4 (0.60) | CHRM4DUSP3ADORA2BADORA2AADORA1 | |
| SCHEMBL3054323 | 0.84 | DUSP3 (0.63) | CHRM4DUSP3ADORA2BADORA2AADORA1 | |
| SCHEMBL5713555 | 0.83 | ADORA2B (0.80) | CHRM4DUSP3ADORA2BADORA2AADORA1 | |
| SCHEMBL3053652 | 0.83 | ALDH1A1 (0.59) | CHRM4DUSP3ADORA2BADORA2AADORA1 | |
| SCHEMBL20702512 | 0.81 | CHRM4 (0.49) | CHRM4DUSP3ADORA2AADORA1KMT2A | |
| SCHEMBL7147592 | 0.81 | KMT2A (0.64) | CHRM4DUSP3KMT2APOLBMEN1 | |
| SCHEMBL1040609 | 0.81 | SMN1; SMN2 (0.51) | CHRM4DUSP3KMT2APOLBMEN1 | |
| SCHEMBL3045307 | 0.80 | DUSP3 (0.82) | CHRM4DUSP3ADORA1KMT2APOLB | |
| SCHEMBL3047433 | 0.78 | DUSP3 (0.71) | CHRM4DUSP3ADORA2BADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113939520-A | Thiazolopyridine derivatives as adenosine receptor antagonists | 默克专利股份公司 | 2022-01-14 | — | — | CN | disclosed |