Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30513858 | 1.00 | LMNA (0.56) | LMNAPDE10AMAPTGAAHPGD | |
| SCHEMBL23478496 | 0.82 | LMNA (0.61) | LMNAPDE10AMAPTGAAHPGD | |
| SCHEMBL7457013 | 0.82 | LMNA (0.56) | LMNAPDE10AMAPTGAAHPGD | |
| SCHEMBL6630437 | 0.82 | LMNA (0.56) | LMNAPDE10AMAPTGAAHPGD | |
| SCHEMBL24287678 | 0.80 | PDPK1 (0.58) | LMNAMAPTGAAHPGDKMT2A | |
| SCHEMBL16674780 | 0.79 | GAA (0.51) | LMNAPDE10AMAPTGAAHPGD | |
| SCHEMBL28478793 | 0.79 | SMN1; SMN2 (0.56) | LMNAMAPTGAAHPGDKMT2A | |
| SCHEMBL29691142 | 0.78 | DRD2 (0.55) | LMNAPDE10AMAPTGAAHPGD | |
| SCHEMBL16806283 | 0.78 | LMNA (0.51) | LMNAPDE10AMAPTGAAHPGD | |
| SCHEMBL9037145 | 0.78 | PSMB8 (0.59) | LMNAPDE10AMAPTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113816948-B | Condensed imidazole derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-113816948-A | Condensed imidazole derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2021-12-21 | — | — | CN | disclosed |