Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 6/20 | 0.49 |
| ▸ | BRD4 | O60885 | 4/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.49 |
| ▸ | JUN | P05412 | 4/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28120629 | 0.89 | TTK (0.55) | TTKJAK2BRD4MAPK10JUN | |
| SCHEMBL28678996 | 0.86 | JAK2 (0.50) | TTKJAK2BRD4MAPK10JAK3 | |
| SCHEMBL28120721 | 0.83 | TTK (0.49) | TTKJAK2BRD4MAPK10JUN | |
| SCHEMBL29370855 | 0.83 | TTK (0.61) | TTKJAK2BRD4MAPK10JUN | |
| SCHEMBL18376727 | 0.83 | TTK (0.61) | TTKJAK2BRD4MAPK10JUN | |
| SCHEMBL18376845 | 0.82 | HDAC3 (0.55) | TTKJAK2BRD4MAPK10JUN | |
| SCHEMBL30859695 | 0.82 | TTK (0.65) | TTKJAK2MAPK10JUNMAPK8 | |
| SCHEMBL18376252 | 0.82 | TTK (0.65) | TTKJAK2MAPK10JUNMAPK8 | |
| SCHEMBL18376846 | 0.81 | JAK2 (0.56) | TTKJAK2BRD4MAPK10JUN | |
| SCHEMBL18376851 | 0.79 | JAK2 (0.54) | TTKJAK2BRD4MAPK10JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |