Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 9/20 | 0.56 |
| ▸ | PRKACG | P22612 | 9/20 | 0.56 |
| ▸ | PRKACB | P22694 | 9/20 | 0.56 |
| ▸ | CDK4 | P11802 | 6/20 | 0.56 |
| ▸ | CCND1 | P24385 | 6/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.56 |
| ▸ | CDK2 | P24941 | 4/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.47 |
| ▸ | CDK9 | P50750 | 4/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28681987 | 0.89 | RPS6KB1 (0.60) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL20624145 | 0.89 | CDK4 (0.56) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL28660892 | 0.89 | RPS6KB1 (0.48) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL28101192 | 0.86 | PRKACA (0.76) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL28661712 | 0.86 | CCNT1 (0.53) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL20624155 | 0.83 | CAMK2D (0.58) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL28655141 | 0.81 | PRKACA (0.61) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL20624168 | 0.78 | CCNT1 (0.49) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL20623442 | 0.78 | CCNT1 (0.60) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL28101196 | 0.77 | CDK4 (0.57) | PRKACAPRKACGPRKACBCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-110526903-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2021-12-10 | — | — | CN | disclosed |