Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 13/20 | 0.76 |
| ▸ | PRKACG | P22612 | 13/20 | 0.76 |
| ▸ | PRKACB | P22694 | 13/20 | 0.76 |
| ▸ | CDK4 | P11802 | 7/20 | 0.76 |
| ▸ | CCND1 | P24385 | 7/20 | 0.76 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.76 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.76 |
| ▸ | CDK2 | P24941 | 4/20 | 0.76 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.58 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.57 |
| ▸ | CDK1 | P06493 | 3/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | PRKCG | P05129 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27789768 | 0.88 | PRKACA (0.74) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL28101203 | 0.88 | IDH1 (0.60) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL20624143 | 0.88 | CDK4 (0.76) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL28682000 | 0.86 | PRKACA (0.56) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL20624187 | 0.83 | PRKACA (0.55) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL20624149 | 0.82 | PRKACA (0.54) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL28101312 | 0.81 | SIRT2 (0.54) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL28101295 | 0.81 | CAMK2D (0.76) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9087145 | 0.81 | PRKCB (0.74) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9087563 | 0.80 | PRKACA (0.71) | PRKACAPRKACGPRKACBCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-110526903-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2021-12-10 | — | — | CN | disclosed |
| CN-106146475-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-106083830-A | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2016-11-09 | — | — | CN | disclosed |