Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL22749301 | 0.78 | FFAR4 (0.35) | FFAR4KMT2AALOX5PDE4BTP53 | |
| SCHEMBL22758556 | 0.77 | FFAR4 (0.39) | FFAR4KMT2AALOX5PDE4BPDE4A | |
| SCHEMBL21392151 | 0.77 | FFAR4 (0.37) | FFAR4ALOX5PDE4BPDE4APDE4C | |
| SCHEMBL22749305 | 0.76 | LMNA (0.36) | FFAR4KMT2ALMNAALDH1A1GAA | |
| Lithium SCHEMBL30725900 | 0.76 | FFAR4 (0.38) | FFAR4KMT2AALOX5PDE4BPDE4A | |
| SCHEMBL29142075 | 0.76 | FFAR4 (0.38) | FFAR4KMT2AALOX5PDE4BPDE4A | |
| SCHEMBL21392085 | 0.76 | FFAR4 (0.35) | FFAR4KMT2AALOX5LMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL29368124 | 0.75 | LMNA (0.35) | FFAR4KMT2ALMNAALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL28701070 | 0.75 | LMNA (0.35) | FFAR4KMT2ALMNAALDH1A1GAA | |
| SCHEMBL22762634 | 0.73 | LMNA (0.36) | FFAR4ALOX5TP53LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114008039-B | Compounds as human CTPS1 inhibitors for the treatment of proliferative diseases | 斯泰普制药股份公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-114008039-A | N- (5- (6-ethoxypyrazin-2-yl) pyridin-2-yl) -4- (2- (methylsulfonylamino) pyrimidin-4-yl) tetrahydro-2H-pyran-4-carboxamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases | 斯泰普制药股份公司 | 2022-02-01 | — | — | CN | disclosed |