Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294640 | 0.84 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL5982606 | 0.80 | KCNK3 (0.77) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 | |
| Iodide SCHEMBL30758605 | 0.79 | KCNK3 (0.74) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL25924692 | 0.78 | HDAC1 (0.66) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL13152874 | 0.76 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL126415 | 0.76 | PTPN1 (0.87) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL8000882 | 0.75 | TRPV1 (0.66) | RAB9AMAPTPTPN1KCNK3KDM4E | |
| SCHEMBL29212211 | 0.75 | PTPN1 (0.67) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL7302565 | 0.75 | KCNK9 (0.76) | NPC1RAB9ASMN1; SMN2MAPTPTPN1 | |
| SCHEMBL22465977 | 0.75 | TOP1 (0.41) | NPC1RAB9ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114025847-A | Compounds and compositions as modulators of TLR signaling | 神经孔疗法股份有限公司 | 2022-02-08 | — | — | CN | disclosed |