Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294640 | 0.82 | NPC1 (0.58) | KCNK3PTPN1HDAC2HDAC3HDAC1 | |
| SCHEMBL3680858 | 0.81 | KMT2A (0.71) | TRPV1KCNK3PTPN1HDAC2HDAC8 | |
| SCHEMBL3638309 | 0.81 | KCNK3 (0.82) | KCNK3PTPN1HDAC2HDAC8HDAC6 | |
| SCHEMBL846453 | 0.80 | TRPV1 (1.00) | TRPV1KDM4ERAB9A | |
| SCHEMBL9525533 | 0.80 | TRPV1 (0.54) | TRPV1CA12CA9ALDH1A1KDM4E | |
| SCHEMBL23762213 | 0.80 | HPGD (0.62) | TRPV1ALDH1A1MAPTRAB9A | |
| SCHEMBL14095548 | 0.80 | HDAC6 (0.57) | TRPV1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL11146761 | 0.77 | HCAR3 (0.58) | TRPV1CA12CA9ALDH1A1TSHR | |
| SCHEMBL1315526 | 0.77 | PTPN1 (0.87) | KCNK3PTPN1HDAC2HDAC8HDAC6 | |
| SCHEMBL16615792 | 0.77 | HDAC1 (0.63) | TRPV1CA12CA1CA9PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294569-B2 | ANALGESIC AT CENTRAL NERVOUS SYSTEM IN THE MAMMALIAN SUBJECT. ALSO, THESE COMPOUNDS ARE INFLAMMATORY PAIN CAUSED, FOR EXAMPLE BY BURNS (INDUCED BY A CONTACT WITH HEAT, ACID OR THE OTHER RHEUMATISM OR THE LIKE, IN THE SAID SUBJECT. | PFIZER INC. | 2001-09-25 | — | — | US | disclosed |