Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.40 |
| ▸ | FLT1 | P17948 | 5/20 | 0.40 |
| ▸ | FLT4 | P35916 | 4/20 | 0.40 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.40 |
| ▸ | STK10 | O94804 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28686017 | 0.90 | ALDH1A1 (0.43) | KDRPDGFRAFLT1MAPK1PRMT1 | |
| SCHEMBL29837315 | 0.89 | KDR (0.45) | KDRPDGFRAFLT1KITMAPK14 | |
| SCHEMBL28933364 | 0.89 | GAA (0.44) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL2973081 | 0.89 | KDR (0.45) | KDRPDGFRAFLT1KITMAPK14 | |
| SCHEMBL28698586 | 0.87 | PRMT1 (0.37) | KDRPDGFRAFLT1ABL1SRC | |
| SCHEMBL28697205 | 0.87 | BRAF (0.40) | KDRFLT1PRMT1BRAFALDH1A1 | |
| SCHEMBL9909777 | 0.87 | BRAF (0.41) | KDRFLT1PRMT1BRAFALDH1A1 | |
| SCHEMBL29396856 | 0.87 | BRAF (0.41) | KDRFLT1PRMT1BRAFALDH1A1 | |
| SCHEMBL29662384 | 0.87 | KDR (0.43) | KDRPDGFRAFLT1PRMT1BRAF | |
| SCHEMBL28706536 | 0.87 | KDR (0.43) | KDRPDGFRAFLT1PRMT1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114144410-A | Polyarylurea derivatives and their use in the treatment of muscular diseases | 阿纳格纳斯生物技术股份有限公司 | 2022-03-04 | — | — | CN | disclosed |