Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2973081 | 0.89 | KDR (0.45) | BRAFKDRFLT1 | |
| SCHEMBL29837315 | 0.89 | KDR (0.45) | BRAFKDRFLT1 | |
| SCHEMBL28686017 | 0.88 | ALDH1A1 (0.43) | BRAFKDRFLT1PRMT1MAPT | |
| SCHEMBL28686012 | 0.87 | KDR (0.40) | BRAFKDRFLT1PRMT1MAPT | |
| SCHEMBL28706536 | 0.87 | KDR (0.43) | BRAFKDRFLT1PRMT1MAPT | |
| SCHEMBL28933364 | 0.87 | GAA (0.44) | KDRFLT1PRMT1MAPTPOLB | |
| SCHEMBL29662384 | 0.87 | KDR (0.43) | BRAFKDRFLT1PRMT1MAPT | |
| SCHEMBL28708282 | 0.87 | BRAF (0.43) | BRAFKDRFLT1AAK1LMNA | |
| SCHEMBL9909777 | 0.85 | BRAF (0.41) | BRAFKDRFLT1PRMT1ALDH1A1 | |
| SCHEMBL28698586 | 0.85 | PRMT1 (0.37) | KDRFLT1AAK1PRMT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999057-A1 | POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES | ANAGENESIS BIOTECHNOLOGIES SAS (FR) | 2022-05-25 | — | — | EP | disclosed |
| CN-114144410-A | Polyarylurea derivatives and their use in the treatment of muscular diseases | 阿纳格纳斯生物技术股份有限公司 | 2022-03-04 | — | — | CN | disclosed |