SCHEMBL28688482

SCHEMBL28688482

CNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C[O])[C@@H](O)C1(Cl)Cl

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 12/20 0.57
ADORA1 P30542 11/20 0.57
ADORA2B P29275 8/20 0.52
PGK1 P00558 1/20 0.43
PGK2 P07205 1/20 0.43
ADORA2A P29274 5/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23927951 0.91 ADORA3 (0.66) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL31140789 0.91 ADORA3 (0.66) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL28678580 0.90 ADORA3 (0.55) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL28932189 0.88 ADORA3 (0.57) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL28601543 0.87 ADORA3 (0.56) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL28678710 0.85 ADORA3 (0.54) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL31140757 0.81 ADORA3 (0.64) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL23927944 0.81 ADORA3 (0.64) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL30901676 0.81 ADORA3 (0.64) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL25382883 0.81 ADORA3 (0.64) ADORA3ADORA1ADORA2BPGK1PGK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113784721-A High activity compound for resisting COVID-19 阿堤亚制药公司 2021-12-10 CN disclosed