Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | PRKCA | P17252 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8934337 | 0.80 | ALDH1A1 (0.50) | ALDH1A1ZDHHC7CYP3A4FAAHPRKCA | |
| SCHEMBL6966711 | 0.79 | TDP1 (0.46) | ALDH1A1USP2CYP3A4MAPTHPGD | |
| SCHEMBL30522611 | 0.78 | PRSS1 (0.51) | ALDH1A1ZDHHC7CYP3A4MAPTFAAH | |
| SCHEMBL17676317 | 0.78 | PRSS1 (0.51) | ALDH1A1ZDHHC7CYP3A4MAPTFAAH | |
| SCHEMBL19025418 | 0.78 | PRSS1 (0.51) | ALDH1A1ZDHHC7CYP3A4MAPTFAAH | |
| SCHEMBL18723036 | 0.78 | PRSS1 (0.51) | ALDH1A1ZDHHC7CYP3A4MAPTFAAH | |
| SCHEMBL4582699 | 0.78 | PRSS1 (0.51) | ALDH1A1ZDHHC7CYP3A4MAPTFAAH | |
| SCHEMBL18856287 | 0.78 | PRSS1 (0.51) | ALDH1A1ZDHHC7CYP3A4MAPTFAAH | |
| SCHEMBL19025446 | 0.78 | PRSS1 (0.51) | ALDH1A1ZDHHC7CYP3A4MAPTFAAH | |
| SCHEMBL14525664 | 0.78 | FAAH (0.49) | ALDH1A1ZDHHC7MAPTFAAHPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2543390-A1 | Pharmaceutical composition | Kyowa Hakko Kirin Co., Ltd. (JP) | 2013-01-09 | — | — | EP | claimed |
| US-20100098690-A1 | PHARMACEUTICAL COMPOSITION | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-04-22 | — | — | US | claimed |
| CN-101641117-A | Pharmaceutical composition | KYOWA HAKKO KOGYO KK JP | 2010-02-03 | — | — | CN | claimed |
| EP-2133094-A1 | PHARMACEUTICAL COMPOSITION | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-12-16 | — | — | EP | claimed |
| US-20090042883-A1 | ANTITUMOR AGENT | KYOWA HAKKOKOGYO CO. (JP) | 2009-02-12 | — | — | US | claimed |
| CN-101123954-A | Antitumor agent | KYOWA HAKKO KOGYO KK (JP) | 2008-02-13 | — | — | CN | claimed |
| EP-1852112-A1 | ANTI-TUMOR AGENT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-11-07 | — | — | EP | claimed |
| US-20070032532-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-02-08 | — | — | US | claimed |
| CN-1791568-A | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO KK (JP) | 2006-06-21 | — | — | CN | claimed |
| EP-1642880-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-05 | — | — | EP | claimed |
| EP-2543390-A1 | Pharmaceutical composition | Kyowa Hakko Kirin Co., Ltd. (JP) | 2013-01-09 | — | — | EP | disclosed |
| CN-101641117-B | Pharmaceutical composition | KYOWA HAKKO KIRIN CO LTD | 2012-06-13 | — | — | CN | disclosed |
| CN-101123954-B | ANTITUMOR AGENT | KYOWA HAKKO KOGYO KK | 2011-07-13 | — | — | CN | disclosed |
| US-7767693-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20100104567-A1 | PHARMACEUTICAL COMPOSITION | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-04-29 | — | — | US | disclosed |
| CN-101123954-A | Antitumor agent | KYOWA HAKKO KOGYO KK (JP) | 2008-02-13 | — | — | CN | disclosed |
| EP-1852112-A1 | ANTI-TUMOR AGENT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-11-07 | — | — | EP | disclosed |
| US-20070032532-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-02-08 | — | — | US | disclosed |
| CN-1791568-A | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO KK (JP) | 2006-06-21 | — | — | CN | disclosed |
| EP-1642880-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032532-A1 | Hsp90 family protein inhibitors | HSP90AB1, HSP90B1, HSP90AB2P | ALDH1A1 2940/4885ZDHHC7 1528/4885USP2 1864/4885 |
| US-20090042883-A1 | ANTITUMOR AGENT | MCL1, HDAC7, TP53 | ALDH1A1 780/4885ZDHHC7 971/4885USP2 3970/4885 |
| US-20100104567-A1 | PHARMACEUTICAL COMPOSITION | FLT4, FLT3, FLT1 | ALDH1A1 2291/4885ZDHHC7 4561/4885USP2 4147/4885 |
| US-20100098690-A1 | PHARMACEUTICAL COMPOSITION | HSP90B1, HSP90AB1, HSP90AB2P | ALDH1A1 2884/4885ZDHHC7 2316/4885USP2 2205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.