Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ECE1 | P42892 | 6/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL8936380 | 0.91 | KDM4E (0.61) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL5314267 | 0.90 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28171407 | 0.90 | KDM4E (0.74) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28790481 | 0.90 | KDM4E (0.74) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28827035 | 0.89 | KDM4E (0.64) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28697957 | 0.89 | KDM4E (0.76) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28438691 | 0.89 | KDM4E (0.48) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL10428528 | 0.88 | KDM4E (0.65) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL10428526 | 0.88 | KDM4E (0.65) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL7267888 | 0.87 | KDM4E (0.63) | KDM4EMAPTLMNATSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114163354-B | Preparation method of N-fluorenylmethoxycarbonyl-N-trityl-L-asparagine | 常州吉恩药业有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-114163354-A | Preparation method of N-fluorenylmethoxycarbonyl-N-trityl-L-asparagine | 常州吉恩药业有限公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-108707189-B | Antibacterial cyclic peptide and preparation method and application thereof | 安徽工程大学 | 2022-03-08 | — | — | CN | disclosed |