Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | BLM | P54132 | 2/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | MPO | P05164 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.74 |
| ▸ | APAF1 | O14727 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ECE1 | P42892 | 5/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28171407 | 1.00 | KDM4E (0.74) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL3442897 | 0.96 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL531051 | 0.95 | KDM4E (0.82) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL2005670 | 0.95 | KDM4E (0.82) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL2143522 | 0.95 | KDM4E (0.82) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL8936315 | 0.94 | KDM4E (0.65) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7267888 | 0.92 | KDM4E (0.63) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6033338 | 0.92 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL7056081 | 0.92 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL424583 | 0.92 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101952433-B | PTHrP, its subtypes and antagonists thereof in diagnosis and treatment of diseases | BIOCHROM PHARMA INC | 2014-12-10 | — | — | CN | disclosed |
| CN-101952433-A | PTHrP, its subtypes and antagonists thereof in diagnosis and treatment of diseases | BIOCHROM PHARMA INC | 2011-01-19 | — | — | CN | disclosed |