Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KISS1R | Q969F8 | 11/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | IL1RN | P18510 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL28689794 | 0.89 | KDM4E (0.60) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL8936380 | 0.88 | KDM4E (0.61) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL7267888 | 0.87 | KDM4E (0.63) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL4295680 | 0.86 | KDM4E (0.59) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL6473524 | 0.86 | KMT2A (0.54) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL6473526 | 0.86 | KMT2A (0.54) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL10428526 | 0.85 | KDM4E (0.65) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28202459 | 0.85 | KDM4E (0.65) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL10428528 | 0.85 | KDM4E (0.65) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL293836 | 0.85 | MEN1 (0.49) | KDM4EMAPTMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106046125-B | CTL epitope peptide on HTNV GP as well as screening method and application thereof | 中国人民解放军第四军医大学 | 2020-04-24 | — | — | CN | disclosed |