Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.57 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.30 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31626720 | 0.81 | HSD11B1 (0.57) | HSD11B1HSD11B2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL26918602 | 0.79 | — | — | |
| SCHEMBL30832718 | 0.79 | HSD11B1 (0.44) | HSD11B1HSD11B2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL1439352 | 0.79 | — | — | |
| SCHEMBL14273569 | 0.79 | HSD11B1 (0.55) | HSD11B1HSD11B2 | |
| SCHEMBL6127513 | 0.77 | HSD11B1 (0.42) | HSD11B1HSD11B2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL6127508 | 0.77 | HSD11B1 (0.42) | HSD11B1HSD11B2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL15640955 | 0.76 | HSD11B1 (0.37) | HSD11B1HSD11B2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL14801335 | 0.76 | HSD11B1 (0.41) | HSD11B1HSD11B2 | |
| SCHEMBL14801334 | 0.76 | HSD11B1 (0.41) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114127080-A | Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compounds, and methods of use thereof | 捷思英达医药技术（上海）有限公司 | 2022-03-01 | — | — | CN | disclosed |