Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.58 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CRACR2A | Q9BSW2 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859024 | 0.83 | ABCC8 (0.53) | LMNAABCC8KCNJ11MAPTRAB9A | |
| SCHEMBL2863835 | 0.81 | CBLB (0.48) | LMNAABCC8KCNJ11 | |
| SCHEMBL2864396 | 0.81 | USP36 (0.52) | LMNAABCC8KCNJ11MAPTCRACR2A | |
| SCHEMBL12852342 | 0.80 | ABCC8 (0.50) | LMNAABCC8KCNJ11MAPTKDM4E | |
| SCHEMBL2872524 | 0.80 | ABCC8 (0.58) | ABCC8KCNJ11NPC1MEN1KMT2A | |
| SCHEMBL2859438 | 0.79 | ABCC8 (0.49) | LMNAABCC8KCNJ11GAAKDM4E | |
| SCHEMBL2862957 | 0.78 | ABCC8 (0.49) | ABCC8KCNJ11GAAKDM4ERAB9A | |
| SCHEMBL2868108 | 0.77 | KDM4E (0.55) | LMNAABCC8KCNJ11MAPTKDM4E | |
| SCHEMBL2866592 | 0.77 | MEN1 (0.66) | LMNAABCC8KCNJ11MAPTKDM4E | |
| SCHEMBL2868672 | 0.77 | MEN1 (0.66) | LMNAABCC8KCNJ11MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200457-A1 | 4-Cyclopropyl-1,2,3,-Thiadiazole Compound, Agrohorticultural Plant Disease Controlling Agent And Method Of Using The Same | NIHON NOHYAKU CO., LTD. (JP) | 2008-08-21 | — | — | US | claimed |
| CN-101128445-A | 4-cyclopropyl-1,2,3-thiadiazole derivative, agrohorticultural plant disease controlling agent, and method for using the same | NIHON NOHYAKU CO LTD (JP) | 2008-02-20 | — | — | CN | claimed |
| EP-1852428-A1 | 4-CYCLOPROPYL-1,2,3-THIADIAZOLE COMPOUND, AGROHORTICULTURAL PLANT DISEASE CONTROLLING AGENT AND METHOD OF USING THE SAME | Nihon Nohyaku Co., Ltd. (JP) | 2007-11-07 | — | — | EP | claimed |
| CN-101128445-B | 4-cyclopropyl-1,2,3-thiadiazole derivative, agrohorticultural plant disease controlling agent, and method for using the same | NIHON NOHYAKU CO LTD | 2012-01-18 | — | — | CN | disclosed |
| US-7786040-B2 | 4-cyclopropyl-1,2,3,-thiadiazole compound, agrohorticultural plant disease controlling agent and method of using the same | NIHON NOHYAKU CO., LTD. (JP) | 2010-08-31 | — | — | US | disclosed |
| US-20080200457-A1 | 4-Cyclopropyl-1,2,3,-Thiadiazole Compound, Agrohorticultural Plant Disease Controlling Agent And Method Of Using The Same | NIHON NOHYAKU CO., LTD. (JP) | 2008-08-21 | — | — | US | disclosed |
| CN-101128445-A | 4-cyclopropyl-1,2,3-thiadiazole derivative, agrohorticultural plant disease controlling agent, and method for using the same | NIHON NOHYAKU CO LTD (JP) | 2008-02-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200457-A1 | 4-Cyclopropyl-1,2,3,-Thiadiazole Compound, Agrohorticultural Plant Disease Controlling Agent And Method Of Using The Same | CBR3, CBR1, OSR1 | LMNA 4471/4885ABCC8 1005/4885KCNJ11 1207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.