Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 1/20 | 0.49 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859024 | 0.81 | ABCC8 (0.53) | ABCC8KCNJ11KMT2AUSP2NPC1 | |
| SCHEMBL20302009 | 0.77 | L3MBTL1 (0.44) | KMT2AUSP2NPC1RAB9AEPHB3 | |
| SCHEMBL12855223 | 0.75 | ATM (0.49) | ABCC8KCNJ11KMT2AUSP2NPC1 | |
| SCHEMBL12852342 | 0.73 | ABCC8 (0.50) | ABCC8KCNJ11KMT2AKDM4E | |
| SCHEMBL2866454 | 0.71 | SMN1; SMN2 (0.57) | KMT2ANPC1RAB9AKDM4ECYP1A2 | |
| SCHEMBL24093709 | 0.70 | KDM4E (0.49) | KMT2AUSP2NPC1RAB9AEPHB3 | |
| SCHEMBL29395460 | 0.70 | ALDH1A1 (0.48) | KMT2ANPC1RAB9AEPHB3KDM4E | |
| SCHEMBL22380 | 0.70 | ALDH1A1 (0.48) | KMT2ANPC1RAB9AEPHB3KDM4E | |
| SCHEMBL2872524 | 0.70 | ABCC8 (0.58) | ABCC8KCNJ11KMT2AUSP2NPC1 | |
| SCHEMBL2868146 | 0.69 | ABCC8 (0.47) | ABCC8KCNJ11KDM4EGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852428-B1 | 4-CYCLOPROPYL-1,2,3-THIADIAZOLE COMPOUND, AGROHORTICULTURAL PLANT DISEASE CONTROLLING AGENT AND METHOD OF USING THE SAME | NIHON NOHYAKU CO LTD (JP) | 2012-05-16 | — | — | EP | disclosed |
| US-7786040-B2 | 4-cyclopropyl-1,2,3,-thiadiazole compound, agrohorticultural plant disease controlling agent and method of using the same | NIHON NOHYAKU CO., LTD. (JP) | 2010-08-31 | — | — | US | disclosed |
| US-20080200457-A1 | 4-Cyclopropyl-1,2,3,-Thiadiazole Compound, Agrohorticultural Plant Disease Controlling Agent And Method Of Using The Same | NIHON NOHYAKU CO., LTD. (JP) | 2008-08-21 | — | — | US | disclosed |
| EP-1852428-A1 | 4-CYCLOPROPYL-1,2,3-THIADIAZOLE COMPOUND, AGROHORTICULTURAL PLANT DISEASE CONTROLLING AGENT AND METHOD OF USING THE SAME | Nihon Nohyaku Co., Ltd. (JP) | 2007-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200457-A1 | 4-Cyclopropyl-1,2,3,-Thiadiazole Compound, Agrohorticultural Plant Disease Controlling Agent And Method Of Using The Same | CBR3, CBR1, OSR1 | ABCC8 1005/4885KCNJ11 1207/4885KMT2A 2053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.