Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22831659 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL2238946 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1MAPTPOLBCYP2A6 | |
| SCHEMBL22831632 | 0.79 | CA1 (0.41) | SMN1; SMN2ALDH1A1MAPTNPC1HTT | |
| SCHEMBL22683593 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1MAPTPOLBCYP2A6 | |
| SCHEMBL22683616 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1HTTKMT2ACYP2A6 | |
| SCHEMBL22831644 | 0.77 | NPBWR1 (0.40) | SMN1; SMN2ALDH1A1MAPTPAX8CYP2A6 | |
| SCHEMBL10772427 | 0.77 | TOP2A (0.47) | ALDH1A1MAPTNPC1RAB9AKMT2A | |
| SCHEMBL28697965 | 0.74 | NOTUM (0.55) | SMN1; SMN2ALDH1A1MAPTNPC1HTT | |
| SCHEMBL22831636 | 0.68 | HPGD (0.54) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL17596865 | 0.68 | BACE1 (0.42) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259212-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-08-18 | — | — | US | disclosed |
| EP-3997083-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE | Idorsia Pharmaceuticals Ltd (CH) | 2022-05-18 | — | — | EP | disclosed |
| CN-114127066-A | Inhibitors of indoleamine 2, 3-dioxygenase and/or tryptophan 2, 3-dioxygenase | 爱杜西亚药品有限公司 | 2022-03-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259212-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE | IDO2, TDO2, IDO1 | SMN1; SMN2 4731/4885ALDH1A1 570/4885MAPT 3377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.