Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TTR | P02766 | 2/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29562473 | 0.79 | MEN1 (0.40) | TDP1KMT2AMEN1TTRALB | |
| SCHEMBL22832045 | 0.79 | MEN1 (0.40) | TDP1KMT2AMEN1TTRALB | |
| SCHEMBL29562072 | 0.79 | GRM6 (0.35) | TDP1KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22832130 | 0.79 | GRM6 (0.35) | TDP1KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18153628 | 0.77 | MEN1 (0.57) | TDP1KMT2AMEN1TTRALB | |
| SCHEMBL22831952 | 0.77 | TDP1 (0.38) | TDP1THRBNPSR1ALDH1A1LMNA | |
| SCHEMBL29561777 | 0.77 | TDP1 (0.38) | TDP1THRBNPSR1ALDH1A1LMNA | |
| SCHEMBL22831965 | 0.76 | LMNA (0.35) | TDP1KMT2AMEN1TTRSMN1; SMN2 | |
| SCHEMBL22832036 | 0.76 | LMNA (0.35) | KMT2ASMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL22831931 | 0.76 | LMNA (0.35) | KMT2AMEN1SMN1; SMN2NPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026073-A | Quinazolin-4-one derivatives for the treatment of BRAF related diseases and disorders | ARRAY生物制药公司 | 2022-02-08 | — | — | CN | disclosed |