Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22832130 | 1.00 | GRM6 (0.35) | GRM6LMNASMN1; SMN2POLBMAPT | |
| SCHEMBL29562473 | 0.88 | MEN1 (0.40) | GRM6LMNASMN1; SMN2POLBMAPT | |
| SCHEMBL22832045 | 0.88 | MEN1 (0.40) | GRM6LMNASMN1; SMN2POLBMAPT | |
| SCHEMBL22832036 | 0.87 | LMNA (0.35) | GRM6LMNASMN1; SMN2POLBMAPT | |
| SCHEMBL29561992 | 0.87 | LMNA (0.35) | GRM6LMNASMN1; SMN2POLBMAPT | |
| SCHEMBL22831965 | 0.87 | LMNA (0.35) | GRM6LMNASMN1; SMN2POLBMAPT | |
| SCHEMBL29562048 | 0.87 | LMNA (0.35) | GRM6LMNASMN1; SMN2POLBMAPT | |
| SCHEMBL22831892 | 0.85 | LMNA (0.40) | LMNASMN1; SMN2POLBMAPTTDP1 | |
| SCHEMBL29562065 | 0.85 | LMNA (0.40) | LMNASMN1; SMN2POLBMAPTTDP1 | |
| SCHEMBL22831931 | 0.84 | LMNA (0.35) | GRM6LMNASMN1; SMN2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026073-B | Quinazolin-4-one derivatives for the treatment of BRAF related diseases and disorders | ARRAY生物制药公司 | 2024-08-23 | — | — | CN | disclosed |
| EP-3990437-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | Array Biopharma, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |