Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 9/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | TACR3 | P29371 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | UBE2I | P63279 | 2/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28673422 | 0.92 | MEN1 (0.59) | MCL1TACR3CYP3A4APOBEC3AAPOBEC3G | |
| SCHEMBL28931754 | 0.91 | MEN1 (0.59) | MCL1CYP3A4APOBEC3AAPOBEC3GTDP1 | |
| SCHEMBL28672796 | 0.89 | MCL1 (0.46) | MCL1PLA2G2ACACNA1BAPBA1STAT3 | |
| SCHEMBL28681436 | 0.88 | STAT3 (0.61) | MCL1CYP3A4APOBEC3AAPOBEC3GTDP1 | |
| SCHEMBL28680477 | 0.85 | MCL1 (0.57) | MCL1STAT3 | |
| SCHEMBL28673390 | 0.84 | MCL1 (0.65) | MCL1 | |
| SCHEMBL28683183 | 0.83 | CHEK1 (0.58) | MCL1CYP3A4APOBEC3AAPOBEC3GTDP1 | |
| SCHEMBL28680486 | 0.83 | KDM4E (0.58) | CA12CA1CA2CA9CYP3A4 | |
| SCHEMBL28695985 | 0.82 | STAT3 (0.55) | MCL1CYP3A4APOBEC3AAPOBEC3GTDP1 | |
| SCHEMBL28699093 | 0.82 | CTDSP1 (0.62) | MCL1TACR3APOBEC3AAPOBEC3GTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113747920-A | Immune checkpoint inhibitor combination therapy using quinoline carboxamide derivatives | 株式会社益力多本社 | 2021-12-03 | — | — | CN | disclosed |
| CN-112703001-A | Combination cancer therapy using quinoline carboxamide derivatives | 株式会社益力多本社 | 2021-04-23 | — | — | CN | disclosed |