Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.62 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL6162319 | 0.90 | — | — | |
| Glycine SCHEMBL28222759 | 0.89 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2KDM4EHMGCR | |
| Benzene SCHEMBL28749082 | 0.84 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2KDM4EHMGCR | |
| Tert-Butylamine SCHEMBL29128848 | 0.84 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2KDM4EHMGCR | |
| Glycine SCHEMBL9112732 | 0.83 | — | — | |
| Trichloroacetic Acid SCHEMBL3784104 | 0.81 | TSHR (0.62) | GLRA1SLC6A9OR51E2KDM4ETSHR | |
| Glycine SCHEMBL2340760 | 0.79 | — | — | |
| Glycine SCHEMBL2299139 | 0.79 | — | — | |
| Glycine SCHEMBL246859 | 0.79 | GLRA1 (0.83) | GLRA1SLC6A9OR51E2KDM4ETSHR | |
| Glycine SCHEMBL28317820 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 203 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118255796-A | Tool molecule for exploring targeting property of BPA boron-like drug in tumor tissue and method for detecting distribution of BPA boron-like drug in tumor tissue | 兰州大学 | 2024-06-28 | — | — | CN | claimed |
| CN-116836188-A | Probe prodrug and probe for detecting OX-LDL and application of probe for detecting vascular atherosclerosis | 南京大学 | 2023-10-03 | — | — | CN | claimed |
| CN-106146612-B | A kind of glyoxalase I irreversible inhibitor and its preparation method and application | 成都大学 | 2019-09-27 | — | — | CN | claimed |
| CN-110269858-A | It is a kind of to treat twin medicine of cerebral arterial thrombosis and preparation method thereof | 贵州医科大学 | 2019-09-24 | — | — | CN | claimed |
| CN-106008494-B | One kind -2- thioxothiazole alkyl derivative of oxo containing 4- and the preparation method and application thereof | 广东工业大学 | 2019-08-27 | — | — | CN | claimed |
| CN-105037489-B | A kind of glyoxalase I irreversible inhibitor and its preparation method and application | 成都大学 | 2019-01-15 | — | — | CN | claimed |
| CN-108947894-A | Novel biaryl structure chirality N- methylpyridoxal catalyst and its synthesis and application | 上海师范大学 | 2018-12-07 | — | — | CN | claimed |
| CN-105037490-B | A kind of glyoxalase I irreversible inhibitor and its preparation method and application | 深圳永泽医药股份有限公司 | 2018-05-29 | — | — | CN | claimed |
| CN-107903217-A | A kind of preparation method of anagrelide impurity B | 湖北省宏源药业科技股份有限公司 | 2018-04-13 | — | — | CN | claimed |
| CN-106995411-A | A kind of preparation method of the formyl imidazoles of 2 normal-butyl, 4 chlorine 5 | 滨海三甬药业化学有限公司 | 2017-08-01 | — | — | CN | claimed |
| CN-106146612-A | One class GLO-I irreversible inhibitor and its production and use | 成都大学 | 2016-11-23 | — | — | CN | claimed |
| CN-103946218-B | Suppress stable crystal form and the application thereof of the compound of Protocollagen prolyl hydroxylase activity | ZHEJIANG BETA PHARMA INC. (CN) | 2016-03-09 | — | — | CN | claimed |
| CN-105037490-A | Glyoxalase I irreversible inhibitor, preparation method and application thereof | UNIV CHENGDU | 2015-11-11 | — | — | CN | claimed |
| CN-105037489-A | Glyoxalase I irreversible inhibitor, preparation method and application thereof | UNIV CHENGDU | 2015-11-11 | — | — | CN | claimed |
| CN-103946218-A | Stable polymorphic forms of compound as hypoxia mimetics, and uses thereof | BEIJING BETA PHARMA INC | 2014-07-23 | — | — | CN | claimed |
| CN-103214383-A | Process for synthesis of tert-butyl glycinate and further synthesis of N-protected tert-butyl glycinate | SICHUAN TONGSHENG AMINO ACID CO LTD | 2013-07-24 | — | — | CN | claimed |
| CN-118255796-A | Tool molecule for exploring targeting property of BPA boron-like drug in tumor tissue and method for detecting distribution of BPA boron-like drug in tumor tissue | 兰州大学 | 2024-06-28 | — | — | CN | disclosed |
| CN-116836188-A | Probe prodrug and probe for detecting OX-LDL and application of probe for detecting vascular atherosclerosis | 南京大学 | 2023-10-03 | — | — | CN | disclosed |
| CN-1107144-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AG (DE) | 1995-08-23 | — | — | CN | disclosed |
| CN-1065063-A | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1992-10-07 | — | — | CN | disclosed |