Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 3/20 | 0.50 |
| ▸ | GRM6 | O15303 | 3/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286995 | 1.00 | GRM8 (0.50) | GRM8GRM6GRM4ALDH1A1MAPT | |
| SCHEMBL15887345 | 0.90 | ALDH1A1 (0.50) | GRM8GRM6GRM4ALDH1A1MAPT | |
| SCHEMBL27541170 | 0.89 | ALDH1A1 (0.51) | GRM8GRM6GRM4ALDH1A1MAPT | |
| SCHEMBL4142382 | 0.87 | GRM8 (0.50) | GRM8GRM4TSHRGPR35AKR1C3 | |
| SCHEMBL11444826 | 0.86 | GRM4 (0.49) | GRM8GRM6GRM4ALDH1A1MAPT | |
| SCHEMBL31212652 | 0.84 | TSHR (0.57) | GRM8GRM6GRM4ALDH1A1MAPT | |
| SCHEMBL18458413 | 0.84 | ALDH1A1 (0.49) | ALDH1A1TSHRL3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL31430568 | 0.83 | MT-CO2 (0.50) | GRM8GRM6GRM4ALDH1A1MAPT | |
| SCHEMBL11681114 | 0.83 | MT-CO2 (0.50) | GRM8GRM6GRM4ALDH1A1MAPT | |
| SCHEMBL1026668 | 0.83 | ALDH1A1 (0.56) | GRM8GRM6GRM4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101941950-A | 2-substituted benzo-[d] oxazole-5-propionic acid compound and preparation method and applications thereof | UNIV SHANGHAI JIAOTONG | 2011-01-12 | — | — | CN | claimed |
| EP-0062440-A1 | Process for preparing phenylalkanoic acids and derivatives of benzoxazole therefrom | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | claimed |
| US-4304918-A | Process for preparing benzoxazolyl propionic acid derivatives | RAVIZZA S.P.A. (IT) | 1981-12-08 | — | — | US | claimed |
| US-20150140573-A1 | ASSAYS FOR DETECTING GLUCOSIDASE ACTIVITY | MEGAZYME INTERNATIONAL IRELAND (IE) | 2015-05-21 | — | — | US | disclosed |
| US-8785474-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof to treat pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-8785474-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof to treat pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-8785474-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof to treat pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| WO-2013185771-A1 | ASSAYS FOR DETECTING GLUCOSIDASE ACTIVITY | CARLSBERG A/S, CARLSBERG FORSKNINGSCENTER (DK) | 2013-12-19 | — | — | WO | disclosed |
| EP-2427436-B1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2013-01-09 | — | — | EP | disclosed |
| CN-101941950-B | 2-substituted benzo-[d] oxazole-5-propionic acid compound and preparation method and applications thereof | UNIV SHANGHAI JIAOTONG | 2012-12-26 | — | — | CN | disclosed |
| US-8334315-B2 | Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands | GRUENENTHAL GMBH (DE) | 2012-12-18 | — | — | US | disclosed |
| US-20040209776-A1 | Azole derivatives useful as insecticide | FAROOQ SALEEM | 2004-10-21 | — | — | US | disclosed |
| CN-1533389-A | Azole derivatives useful as insecticide | — | 2004-09-29 | — | — | CN | disclosed |
| EP-1414818-A1 | AZOLE DERIVATIVES USEFUL AS INSECTICIDE | Syngenta Limited (GB) | 2004-05-06 | — | — | EP | disclosed |
| US-6703347-B2 | INSECTICIDES, FUNGICIDES, NEMATOCIDES, MOLLUSCICIDES, AND MITICIDES FOR PLANTS | SYNGENTA LIMITED (GB) | 2004-03-09 | — | — | US | disclosed |
| WO-2003011861-A1 | AZOLE DERIVATIVES USEFUL AS INSECTICIDE | SYNGENTA LIMITED (GB) | 2003-02-13 | — | — | WO | disclosed |
| EP-0062440-A1 | Process for preparing phenylalkanoic acids and derivatives of benzoxazole therefrom | ELI LILLY AND COMPANY (US) | 1982-10-13 | — | — | EP | disclosed |
| US-4304918-A | Process for preparing benzoxazolyl propionic acid derivatives | RAVIZZA S.P.A. (IT) | 1981-12-08 | — | — | US | disclosed |
| US-4304918-A | Process for preparing benzoxazolyl propionic acid derivatives | RAVIZZA S.P.A. (IT) | 1981-12-08 | — | — | US | disclosed |
| US-4016193-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JA) | 1977-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209776-A1 | Azole derivatives useful as insecticide | CYP8B1, HRH2, API5 | GRM8 2974/4885GRM6 3097/4885GRM4 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.