SCHEMBL28699640

SCHEMBL28699640

COC(=O)c1cccc(-c2cccnc2)c1F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 1/20 0.54
KMT2A Q03164 2/20 0.52
ALDH1A1 P00352 3/20 0.50
NR4A2 P43354 3/20 0.49
MAPK1 P28482 1/20 0.49
SLC6A4 P31645 1/20 0.49
SLC6A3 Q01959 1/20 0.49
SLC2A1 P11166 1/20 0.48
CYP11B1 P15538 2/20 0.48
CYP11B2 P19099 2/20 0.48
CYP19A1 P11511 1/20 0.48
KDM4E B2RXH2 3/20 0.47
HSD17B10 Q99714 2/20 0.47
CYP17A1 P05093 1/20 0.47
GABRA1 P14867 1/20 0.46
GABRG2 P18507 1/20 0.46
GABRB3 P28472 1/20 0.46
GABRA3 P34903 1/20 0.46
GABRA2 P47869 1/20 0.46
ABL1 P00519 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13435236 0.85 KMT2A (0.61) CFTRKMT2AALDH1A1NR4A2MAPK1
SCHEMBL29644805 0.85 KMT2A (0.61) CFTRKMT2AALDH1A1NR4A2MAPK1
SCHEMBL30118927 0.85 KMT2A (0.61) CFTRKMT2AALDH1A1NR4A2MAPK1
SCHEMBL15830641 0.84 KMT2A (0.53) CFTRKMT2AALDH1A1NR4A2MAPK1
SCHEMBL13824012 0.83 SLC6A3 (0.64) CFTRKMT2AALDH1A1SLC6A4SLC6A3
SCHEMBL28674023 0.83 KMT2A (0.52) CFTRKMT2AALDH1A1NR4A2MAPK1
SCHEMBL19923176 0.81 SLC6A3 (0.59) CFTRKMT2AALDH1A1SLC6A4SLC6A3
SCHEMBL28677127 0.81 KDM4E (0.47) KMT2AALDH1A1SLC6A4SLC6A3KDM4E
SCHEMBL13824199 0.79 SLC6A3 (0.77) KMT2AALDH1A1SLC6A4SLC6A3KDM4E
SCHEMBL13824067 0.78 SLC6A3 (0.56) CFTRKMT2AALDH1A1SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113979955-B Preparation method of heterocyclic ester compound 河南农业大学 2024-05-14 CN disclosed
CN-113979955-A Preparation method of heterocyclic ester compound 河南农业大学 2022-01-28 CN disclosed