Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.60 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.59 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.59 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.59 |
| ▸ | BRD4 | O60885 | 2/20 | 0.59 |
| ▸ | TNF | P01375 | 1/20 | 0.59 |
| ▸ | IL1B | P01584 | 1/20 | 0.59 |
| ▸ | MAP1LC3B | Q9GZQ8 | 4/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17536561 | 0.91 | CRBN (0.64) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL2382757 | 0.90 | CRBN (0.60) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19436877 | 0.90 | CRBN (0.62) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19453060 | 0.90 | CRBN (0.60) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL30438142 | 0.90 | CRBN (0.62) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL24142000 | 0.89 | CRBN (0.61) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL22940891 | 0.89 | CRBN (0.59) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL21814682 | 0.89 | CRBN (0.61) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL22959613 | 0.89 | CRBN (0.59) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL22636509 | 0.89 | CRBN (0.61) | CRBNIKZF3DDB1IKZF1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174299-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2022-03-11 | — | — | CN | disclosed |