Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13331035 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL2562936 | 0.88 | MAPK14 (0.49) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL29662429 | 0.88 | MAPK14 (0.49) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL2558876 | 0.85 | ALDH1A1 (0.42) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL2555515 | 0.85 | GCK (0.60) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL2561277 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL2555509 | 0.84 | GCK (0.45) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL28708295 | 0.84 | GCK (0.45) | POLBRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL2557702 | 0.80 | GCK (0.44) | SMN1; SMN2ALDH1A1GCKMAPK12MAPK14 | |
| SCHEMBL1988921 | 0.80 | MET (0.48) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999057-A1 | POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES | ANAGENESIS BIOTECHNOLOGIES SAS (FR) | 2022-05-25 | — | — | EP | disclosed |
| CN-114144410-A | Polyarylurea derivatives and their use in the treatment of muscular diseases | 阿纳格纳斯生物技术股份有限公司 | 2022-03-04 | — | — | CN | disclosed |