Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31469118 | 0.84 | KDM4E (0.53) | TDP1ALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL6488941 | 0.84 | KDM4E (0.53) | TDP1ALDH1A1L3MBTL1MEN1LMNA | |
| SCHEMBL30468149 | 0.80 | SLC6A4 (0.38) | MAPK1TDP1ALDH1A1L3MBTL1SLC6A4 | |
| SCHEMBL11804777 | 0.78 | SLC6A4 (0.40) | MAPK1ALDH1A1TSHRSLC6A4SLC6A2 | |
| SCHEMBL6297379 | 0.78 | SLC6A4 (0.45) | SLC6A4SLC6A2SLC6A3LMNAMAPT | |
| SCHEMBL2430370 | 0.78 | SLC6A4 (0.43) | SLC6A4SLC6A2SLC6A3HTR2AKCNH2 | |
| SCHEMBL29029436 | 0.77 | PTGDR2 (0.61) | MAPK1TDP1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL1849118 | 0.77 | MAPK1 (0.52) | MAPK1TDP1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL27402118 | 0.76 | CCR5 (0.60) | ALDH1A1SLC6A4LMNAHTTSMN1; SMN2 | |
| SCHEMBL4447957 | 0.76 | HSP90AA1 (0.39) | MAPK1TDP1ALDH1A1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057626-B | Indole-2, 3-dione derivative, preparation method thereof and anti-liver cancer drug for inhibiting RECQL4 specific expression | 山东第一医科大学(山东省医学科学院) | 2023-06-30 | — | — | CN | disclosed |
| CN-114057626-A | Indole-2, 3-dione derivative, preparation method thereof and anti-liver cancer drug for inhibiting RECQL4 specific expression | 山东第一医科大学(山东省医学科学院) | 2022-02-18 | — | — | CN | disclosed |