Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3501957 | 0.81 | JAK2 (0.53) | ALDH1A1GAANPSR1ATMEGFR | |
| SCHEMBL2882063 | 0.75 | TERT (0.36) | — | |
| SCHEMBL2867747 | 0.68 | JAK2 (0.46) | EGFRKDR | |
| SCHEMBL3501684 | 0.67 | JAK2 (0.55) | GAAKDM4E | |
| SCHEMBL8110759 | 0.65 | EGFR (0.74) | EGFRMAP4K4ERBB2ERBB4 | |
| SCHEMBL13597049 | 0.64 | ALDH1A1 (0.77) | ALDH1A1GAANPSR1ATML3MBTL1 | |
| SCHEMBL11732314 | 0.64 | TERT (0.78) | ALDH1A1GAANPSR1ATMPOLB | |
| SCHEMBL13249161 | 0.64 | JAK2 (0.49) | GAAKDM4E | |
| SCHEMBL25233242 | 0.64 | ALDH1A1 (0.71) | ALDH1A1GAANPSR1ATML3MBTL1 | |
| Hydrochloric Acid SCHEMBL11732400 | 0.63 | TERT (0.74) | ALDH1A1GAANPSR1ATMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |